Die unten stehende Tabelle zeigt klinische Studien, die die Auswirkung von oral verabreichten Glucocorticoiden auf Sarkoidosepatienten erforscht haben.
First author |
Year |
No. of patients |
Type of disease |
Type of study |
Active Treatment |
Follow-up |
Results |
ref. no. |
(years) |
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Young (562) |
1970 |
25 |
Dlco abnormal or |
1 – 2 |
No difference in Dlco, VC |
||
Pao² <80mm Hg |
Alternate patients treated |
60mg (1mo) |
or Pao² at rest and exercise |
||||
20mg (5mo) |
|||||||
Harkleroad |
1982 |
17 |
Follow-up of the |
patients of Young et al. |
10 – 15 |
As above |
|
(568) |
|||||||
Hapke |
1971 |
32 |
Stage I 2 |
4 |
Radiographic improvement during |
||
(563) |
Stage II 20 |
Matched Controls; |
15mg ( 6 mo) |
treatment phase; no difference in 4 |
|||
Stage III 10 |
alternate patients treated |
years |
|||||
Israel |
1973 |
90 |
Stage I 37 |
Open, randomized to |
1 |
Stage I no difference at any time |
|
(564) |
II-III 46 |
treatment or no treatment |
15mg ( 3 mo) |
point; II-III: improvement at 3 mo, but |
|||
not after 1 year |
|||||||
Mikami |
1974 |
101 |
Active |
1 |
More rapid radiographic improvement |
||
(565) |
Stage I 39 |
placebo-controlled |
30mg (1 mo) |
in treated patients; no difference at |
|||
Stage II 30 |
20mg (1 mo) |
1-year follow-up |
|||||
10mg (1 mo) |
|||||||
5mg (3 mo) |
|||||||
Selroos |
1979 |
39 |
Stage II not |
Open, randomized to no |
2 |
Treated patients better at 7 mo (x-ray, |
|
(566) |
improving |
treatment or to daily or |
32-20mg (1 mo) |
VC, Dlco) but no difference at 1 or 2 |
|||
spontaneously |
alternate day treatment |
12-16mg (5 mo) |
years; no difference between daily |
||||
4-8mg (1 mo) |
and alternate day therapy |
||||||
Eule |
1980 |
209 |
Stage I 86 |
Open, not randomized |
3 |
More rapid radiographic improvement in |
|
(567) |
StageII 123 |
(78 patients left untreated) |
40mg (1 mo) |
the treated groups; no differences at |
|||
35-15mg (5 mo) |
18, 24 or 36 months in VC or chest |
||||||
10mg (10 or 4 mo) |
radiographs |
||||||
Böttger |
1980 |
317 |
Stage I – II |
Open, not randomized; |
2 |
Relapse rate 20-25% irrespective of |
|
(569) |
Duration <2 y |
100 untreated controls |
20 – 25mg (initial |
treatment schedule |
|||
dose) 14-28 mo |
|||||||
Tachibana |
1981 |
118 |
Stage I 69 |
Open, not randomized, |
0.5 – 2 |
Steroid-treated group better at 6 mo |
|
(570) |
Stage II 49 |
38 treated, 80 not |
alternate days |
and 12 mo but not at 2-year follow-up |
|||
treated |
60 – 40mg (6 mo) |
||||||
30mg (6 mo) |
|||||||
25 – 5mg (6 mo) |
|||||||
Yamamoto |
1983 |
74 |
Stage I 32 |
37 matched pairs of |
as above |
3 |
No difference in resolution rate be- |
(571) |
Stage II 42 |
treated and untreated |
tween treated and untreated patients |
||||
patients |
|||||||
Zaki |
1987 |
183 |
Stage I 64 |
5 |
No difference at any time between |
||
(572) |
Stage II 59 |
40 mg (3 mo) |
treated and untreated patients in |
||||
Stage III 19 |
placebo-controlled |
20 mg (21 mo) |
chest x-ray or lung function tests |
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Other 17 |
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